PHARMACOKINETIC AND CLINICAL EVALUATION OF CEFPIROME IN THE PEDIATRIC FIELD

Pharmacokinetic and clinical evaluations of cefpirome (CPR), a newly developed cephalosporin, were performed in the field of pediatrics. The results are summarized as follows. 1. Peak serum concentrations cf CPR after a dose of 20 mg/kg via 30 minutes and that via 60 minutes intravenous drip infusio...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1991/04/25, Vol.44(4), pp.426-439
Main Authors: NAKAZAWA, SUSUMU, SATO, HAJIME, HIRAMA, YUICHI, NARITA, AKIRA, MATSUMOTO, KIMIKO, NAKAZAWA, SINICHI, SUZUKI, HIROYUKI, NAKANISHI, YOSHIKO, NAGAO, KAZUYA, NIINO, KENJI
Format: Article
Language:Japanese
Subjects:
Adolescent
Age Factors
Bacterial Infections - drug therapy
Bacterial Infections - metabolism
Bacterial Infections - microbiology
Cefpirome
Cephalosporins - administration & dosage
Cephalosporins - adverse effects
Cephalosporins - pharmacokinetics
Child
Child, Preschool
Drug Evaluation
Female
Half-Life
Humans
Infant
Infusions, Intravenous
Male
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Summary:Pharmacokinetic and clinical evaluations of cefpirome (CPR), a newly developed cephalosporin, were performed in the field of pediatrics. The results are summarized as follows. 1. Peak serum concentrations cf CPR after a dose of 20 mg/kg via 30 minutes and that via 60 minutes intravenous drip infusion and a dose of 40 mg/kg via 60 minutes intravenous drip infusion were 80.8, 63.7 and 128.8 itg/ml, respectively, with half-lives being 1.41, 1.28 and 1.79 hours, respectively.Urinary excretion rates for CPR in the first 6 hours after administration ranged 66.7-77.1%. 2. The clinical efficacy rate in pediatric infections obtained at daily dose levels ranging 55.6-166.7 mg/kg was 95.7%. 3. The eradication rate for 22 strains identified in the study was 95.5%. 4. Side effects were found in 2 cases of diarrhea. The abnormal laboratory test results were observed in 5 cases with 7 test items (increased number of platelets; 2 cases, increased activity of GOT; 2 cases and increased activity of GPT; 1 case). According to these results, CPR was considered to be a useful antimicrobial agent in pediatric infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.44.426