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Scrophularia buergeriana regulates cytokine production in vitro
The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4...
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| Published in: | Immunopharmacology and immunotoxicology 2009-06, Vol.31 (2), p.246-252 |
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| container_end_page | 252 |
| container_issue | 2 |
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| container_title | Immunopharmacology and immunotoxicology |
| container_volume | 31 |
| creator | Kim, Su-Jin Park, Jeong-Su Myung, Noh-Yil Moon, Phil-Dong Choi, In-Young An, Hyo-Jin Kim, Na-Hyung Na, Ho-Jeong Kim, Dong-Hyun Kim, Min-cheol An, Nyeon-Hyoung Kim, Il-Kwang Lee, Joo-Young Jeong, Hyun-Ja Um, Jae-Young Kim, Hyung-Min Hong, Seung-Heon |
| description | The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages. The MOLT-4 cells were cultured for 24 h in the presence or absence of SB plus concanavalin (con) A. SB plus con A significantly increased the level of interleukin (IL)-2, IL-4 and interferon (IFN)-γ production compared with that of con A alone (approximately 1.79-fold for IL-2, 2-fold for IL-4, and 1.85-fold for IFN-γ, p < 0.05). SB plus recombinant IFN-γ (rIFN-γ) increased the level of IL-12 and NO production compared with rIFN-γ alone. In addition, SB plus rIFN-γ increased the level the iNOS expression on mouse peritoneal macrophages. Overall, SB may have an immune-enhancement effect through cytokine production. |
| doi_str_mv | 10.1080/08923970802432048 |
| format | article |
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However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages. The MOLT-4 cells were cultured for 24 h in the presence or absence of SB plus concanavalin (con) A. SB plus con A significantly increased the level of interleukin (IL)-2, IL-4 and interferon (IFN)-γ production compared with that of con A alone (approximately 1.79-fold for IL-2, 2-fold for IL-4, and 1.85-fold for IFN-γ, p < 0.05). SB plus recombinant IFN-γ (rIFN-γ) increased the level of IL-12 and NO production compared with rIFN-γ alone. In addition, SB plus rIFN-γ increased the level the iNOS expression on mouse peritoneal macrophages. Overall, SB may have an immune-enhancement effect through cytokine production.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.1080/08923970802432048</identifier><identifier>PMID: 18821220</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Antimicrobial agents ; Cells, Cultured ; Concanavalin A - immunology ; Cytokines ; Cytokines - biosynthesis ; g-Interferon ; Humans ; Immune response ; iNOS ; interleukin ; Interleukin 12 ; Interleukin 2 ; Interleukin 4 ; Lymphocytes T ; Macrophages ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - immunology ; Mice ; molt-4 ; Nitric oxide ; Nitric Oxide - biosynthesis ; Nitric Oxide - immunology ; Nitric Oxide Synthase Type II - analysis ; Nitric Oxide Synthase Type II - immunology ; Nitric-oxide synthase ; Peritoneum ; Plant Extracts - immunology ; Plant Extracts - pharmacology ; Scrophularia ; Scrophularia - immunology ; Scrophularia buergeriana</subject><ispartof>Immunopharmacology and immunotoxicology, 2009-06, Vol.31 (2), p.246-252</ispartof><rights>2009 Informa UK Ltd 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-c57df3527b77635c93bc2d96c8e61a6171cd6bfcad38218b37ee79a345d5df3c3</citedby><cites>FETCH-LOGICAL-c436t-c57df3527b77635c93bc2d96c8e61a6171cd6bfcad38218b37ee79a345d5df3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18821220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Su-Jin</creatorcontrib><creatorcontrib>Park, Jeong-Su</creatorcontrib><creatorcontrib>Myung, Noh-Yil</creatorcontrib><creatorcontrib>Moon, Phil-Dong</creatorcontrib><creatorcontrib>Choi, In-Young</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><creatorcontrib>Kim, Na-Hyung</creatorcontrib><creatorcontrib>Na, Ho-Jeong</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Min-cheol</creatorcontrib><creatorcontrib>An, Nyeon-Hyoung</creatorcontrib><creatorcontrib>Kim, Il-Kwang</creatorcontrib><creatorcontrib>Lee, Joo-Young</creatorcontrib><creatorcontrib>Jeong, Hyun-Ja</creatorcontrib><creatorcontrib>Um, Jae-Young</creatorcontrib><creatorcontrib>Kim, Hyung-Min</creatorcontrib><creatorcontrib>Hong, Seung-Heon</creatorcontrib><title>Scrophularia buergeriana regulates cytokine production in vitro</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages. The MOLT-4 cells were cultured for 24 h in the presence or absence of SB plus concanavalin (con) A. SB plus con A significantly increased the level of interleukin (IL)-2, IL-4 and interferon (IFN)-γ production compared with that of con A alone (approximately 1.79-fold for IL-2, 2-fold for IL-4, and 1.85-fold for IFN-γ, p < 0.05). SB plus recombinant IFN-γ (rIFN-γ) increased the level of IL-12 and NO production compared with rIFN-γ alone. In addition, SB plus rIFN-γ increased the level the iNOS expression on mouse peritoneal macrophages. Overall, SB may have an immune-enhancement effect through cytokine production.</description><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Cells, Cultured</subject><subject>Concanavalin A - immunology</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>g-Interferon</subject><subject>Humans</subject><subject>Immune response</subject><subject>iNOS</subject><subject>interleukin</subject><subject>Interleukin 12</subject><subject>Interleukin 2</subject><subject>Interleukin 4</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Mice</subject><subject>molt-4</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - immunology</subject><subject>Nitric Oxide Synthase Type II - analysis</subject><subject>Nitric Oxide Synthase Type II - immunology</subject><subject>Nitric-oxide synthase</subject><subject>Peritoneum</subject><subject>Plant Extracts - immunology</subject><subject>Plant Extracts - pharmacology</subject><subject>Scrophularia</subject><subject>Scrophularia - immunology</subject><subject>Scrophularia buergeriana</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMotlZ_gBuZla5G85hMMiiIFF9QcKGuQyaTaVOnSU0ySv-9KS2ICL2be0m-czgcAE4RvESQwyvIK0wqlk5cEAwLvgeGiBKcY4rIPhiu__MEkAE4CmEOIUowPQQDxDlGGMMhuH1V3i1nfSe9kVndaz_V6bIy83qaXqMOmVpF92GszpbeNb2KxtnM2OzLRO-OwUEru6BPtnsE3h_u38ZP-eTl8Xl8N8lVQcqYK8qallDMasZKQlVFaoWbqlRcl0iWiCHVlHWrZENSMl4TpjWrJCloQ5NQkRG42PimDJ-9DlEsTFC666TVrg-CkTSw5DyR5ztJjBCljBUJRBswNRCC161YerOQfiUQFOt-xb9-k-Zsa97XC938KraFJuBmAxjbOr-Q3853jYhy1TnfemmVCYLs8r_-I59p2cWZkl6Lueu9TRXvSPcDp1ybEQ</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Kim, Su-Jin</creator><creator>Park, Jeong-Su</creator><creator>Myung, Noh-Yil</creator><creator>Moon, Phil-Dong</creator><creator>Choi, In-Young</creator><creator>An, Hyo-Jin</creator><creator>Kim, Na-Hyung</creator><creator>Na, Ho-Jeong</creator><creator>Kim, Dong-Hyun</creator><creator>Kim, Min-cheol</creator><creator>An, Nyeon-Hyoung</creator><creator>Kim, Il-Kwang</creator><creator>Lee, Joo-Young</creator><creator>Jeong, Hyun-Ja</creator><creator>Um, Jae-Young</creator><creator>Kim, Hyung-Min</creator><creator>Hong, Seung-Heon</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Scrophularia buergeriana regulates cytokine production in vitro</title><author>Kim, Su-Jin ; Park, Jeong-Su ; Myung, Noh-Yil ; Moon, Phil-Dong ; Choi, In-Young ; An, Hyo-Jin ; Kim, Na-Hyung ; Na, Ho-Jeong ; Kim, Dong-Hyun ; Kim, Min-cheol ; An, Nyeon-Hyoung ; Kim, Il-Kwang ; Lee, Joo-Young ; Jeong, Hyun-Ja ; Um, Jae-Young ; Kim, Hyung-Min ; Hong, Seung-Heon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-c57df3527b77635c93bc2d96c8e61a6171cd6bfcad38218b37ee79a345d5df3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antimicrobial agents</topic><topic>Cells, Cultured</topic><topic>Concanavalin A - immunology</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>g-Interferon</topic><topic>Humans</topic><topic>Immune response</topic><topic>iNOS</topic><topic>interleukin</topic><topic>Interleukin 12</topic><topic>Interleukin 2</topic><topic>Interleukin 4</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Mice</topic><topic>molt-4</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - immunology</topic><topic>Nitric Oxide Synthase Type II - analysis</topic><topic>Nitric Oxide Synthase Type II - immunology</topic><topic>Nitric-oxide synthase</topic><topic>Peritoneum</topic><topic>Plant Extracts - immunology</topic><topic>Plant Extracts - pharmacology</topic><topic>Scrophularia</topic><topic>Scrophularia - immunology</topic><topic>Scrophularia buergeriana</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Su-Jin</creatorcontrib><creatorcontrib>Park, Jeong-Su</creatorcontrib><creatorcontrib>Myung, Noh-Yil</creatorcontrib><creatorcontrib>Moon, Phil-Dong</creatorcontrib><creatorcontrib>Choi, In-Young</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><creatorcontrib>Kim, Na-Hyung</creatorcontrib><creatorcontrib>Na, Ho-Jeong</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Min-cheol</creatorcontrib><creatorcontrib>An, Nyeon-Hyoung</creatorcontrib><creatorcontrib>Kim, Il-Kwang</creatorcontrib><creatorcontrib>Lee, Joo-Young</creatorcontrib><creatorcontrib>Jeong, Hyun-Ja</creatorcontrib><creatorcontrib>Um, Jae-Young</creatorcontrib><creatorcontrib>Kim, Hyung-Min</creatorcontrib><creatorcontrib>Hong, Seung-Heon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Su-Jin</au><au>Park, Jeong-Su</au><au>Myung, Noh-Yil</au><au>Moon, Phil-Dong</au><au>Choi, In-Young</au><au>An, Hyo-Jin</au><au>Kim, Na-Hyung</au><au>Na, Ho-Jeong</au><au>Kim, Dong-Hyun</au><au>Kim, Min-cheol</au><au>An, Nyeon-Hyoung</au><au>Kim, Il-Kwang</au><au>Lee, Joo-Young</au><au>Jeong, Hyun-Ja</au><au>Um, Jae-Young</au><au>Kim, Hyung-Min</au><au>Hong, Seung-Heon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scrophularia buergeriana regulates cytokine production in vitro</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>31</volume><issue>2</issue><spage>246</spage><epage>252</epage><pages>246-252</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><abstract>The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages. The MOLT-4 cells were cultured for 24 h in the presence or absence of SB plus concanavalin (con) A. SB plus con A significantly increased the level of interleukin (IL)-2, IL-4 and interferon (IFN)-γ production compared with that of con A alone (approximately 1.79-fold for IL-2, 2-fold for IL-4, and 1.85-fold for IFN-γ, p < 0.05). SB plus recombinant IFN-γ (rIFN-γ) increased the level of IL-12 and NO production compared with rIFN-γ alone. In addition, SB plus rIFN-γ increased the level the iNOS expression on mouse peritoneal macrophages. Overall, SB may have an immune-enhancement effect through cytokine production.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18821220</pmid><doi>10.1080/08923970802432048</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 2009-06, Vol.31 (2), p.246-252 |
| issn | 0892-3973 1532-2513 |
| language | eng |
| recordid | cdi_pubmed_primary_18821220 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Animals Antimicrobial agents Cells, Cultured Concanavalin A - immunology Cytokines Cytokines - biosynthesis g-Interferon Humans Immune response iNOS interleukin Interleukin 12 Interleukin 2 Interleukin 4 Lymphocytes T Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Mice molt-4 Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - immunology Nitric Oxide Synthase Type II - analysis Nitric Oxide Synthase Type II - immunology Nitric-oxide synthase Peritoneum Plant Extracts - immunology Plant Extracts - pharmacology Scrophularia Scrophularia - immunology Scrophularia buergeriana |
| title | Scrophularia buergeriana regulates cytokine production in vitro |
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