Development of biodegradable drug releasing polymeric cardiovascular stents and in vitro evaluation

Prednisolone acetate (PA) is insoluble in water and was chosen as a model drug for its anti-inflammatory/anti-proliferative functions. PA is incorporated into the film-based polymeric biodegradable stents to provide controlled local release of the drug during the mechanical support phase. Stent form...

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Bibliographic Details
Published in:Journal of microencapsulation 2009-09, Vol.26 (6), p.501-512
Main Authors: Sar sözen, Can, Ar ca, Betül, H ncal, A. Atilla, Çal, Sema
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Biocompatible Materials - chemistry
biodegradable cardiovascular stents
Biological and medical sciences
Calorimetry, Differential Scanning
chitosan microspheres
Delayed-Action Preparations - chemistry
General pharmacology
in vitro evaluation
Lactic Acid - chemistry
Medical sciences
Microscopy, Electron, Scanning
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
PLGA
Polyglycolic Acid - chemistry
Prednisolone - administration & dosage
Prednisolone - analogs & derivatives
Prednisolone acetate
Spectroscopy, Fourier Transform Infrared
Stents
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Summary:Prednisolone acetate (PA) is insoluble in water and was chosen as a model drug for its anti-inflammatory/anti-proliferative functions. PA is incorporated into the film-based polymeric biodegradable stents to provide controlled local release of the drug during the mechanical support phase. Stent formulations were 3 mm in diameter with lengths of 150 mm. The polymer wall thickness was 145.0 ± 4.0 µm for microsphere-containing PLGA 75 : 25 stents. The ATR-FTIR spectra showed biodegradable stent surfaces were free of drug and microspheres. Incorporation of PA into the stents increased the surface area when compared to empty and microsphere-incorporated stents. PA release from the stents containing chitosan microspheres was slower than the PA-only incorporated stents. The drug release from the stents coated with microsphere-containing PLGA 75 : 25 solutions was determined to be the slowest one (19.1% cumulative PA released in 32 days). The stents formulated with PLGA 75 : 25 polymers were considered to be more promising due to their suitable mechanical properties and controlled release of the drug.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040802465792