Clinical significance of nailfold capillaroscopy in systemic lupus erythematosus: correlation with endothelial cell activation markers and disease activity

Objective: To evaluate whether nailfold capillaroscopy (NC) changes are associated with the main serum endothelial cell activation markers and the disease activity of systemic lupus erythematosus (SLE). Methods: Serum levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), soluble...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2009, Vol.38 (1), p.38-45
Main Authors: Kuryliszyn-Moskal, A., Ciolkiewicz, M., Klimiuk, P. A., Sierakowski, S.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers - blood
Capillaries - pathology
Capillaries - physiopathology
Case-Control Studies
Diseases of the osteoarticular system
E-Selectin - blood
Endothelin-1 - blood
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Female
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - pathology
Lupus Erythematosus, Systemic - physiopathology
Male
Medical sciences
Middle Aged
Nails - blood supply
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Thrombomodulin - blood
Vascular Endothelial Growth Factor A - blood
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Summary:Objective: To evaluate whether nailfold capillaroscopy (NC) changes are associated with the main serum endothelial cell activation markers and the disease activity of systemic lupus erythematosus (SLE). Methods: Serum levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), soluble E-selectin (sE-selectin), and soluble thrombomodulin (sTM) were determined by an enzyme-linked immunosorbent assay (ELISA) in 80 SLE patients and 33 healthy controls. Results: Nailfold capillary abnormalities were seen in 74 out of 80 (92.5%) SLE patients. A normal capillaroscopic pattern or mild changes were found in 33 (41.25%) and moderate severe abnormalities in 47 (58.75%) of all SLE patients. In SLE patients a capillaroscopic score >1 was more frequently associated with the presence of internal organ involvement (p
ISSN:0300-9742
1502-7732
DOI:10.1080/03009740802366050