A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A

Enzymatic reduction of the methylsulfinylxylofuranosyl (MSX) groups in lipoarabinomannan provides proof of the absolute configuration of MSX and a possible biochemical mechanism for oxidative protection in Mycobacterium tuberculosis.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2009-01 (1), p.110
Main Authors: Stalford, Susanne A, Fascione, Martin A, Sasindran, Smitha J, Chatterjee, Delphi, Dhandayuthapani, Subramanian, Turnbull, W Bruce
Format: Article
Language:English
Subjects:
Carbohydrates - chemistry
Hydrogen Peroxide - chemistry
Lipopolysaccharides - chemistry
Methionine Sulfoxide Reductases
Mycobacterium tuberculosis - enzymology
Oxidants - chemistry
Oxidation-Reduction
Oxidoreductases - chemistry
Reactive Oxygen Species
Stereoisomerism
Substrate Specificity
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Description
Summary:Enzymatic reduction of the methylsulfinylxylofuranosyl (MSX) groups in lipoarabinomannan provides proof of the absolute configuration of MSX and a possible biochemical mechanism for oxidative protection in Mycobacterium tuberculosis.
ISSN:1359-7345
DOI:10.1039/b817483k