Recurrent infantile myofibromatosis: a report of conservative management and discussion of treatment strategies

Infantile myofibromatosis is a rare proliferative mesenchymal disorder that has a potential for rapid growth and recurrence. Approximately 30% of infantile myofibromatosis lesions present in the head and neck, and some of these can cause significant morbidity. We report a case of recurrent infantile...

Full description

Saved in:
Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2008-12, Vol.87 (12), p.E4
Main Authors: Ebert, Jr, Charles S, Zdanski, Carlton, Ardeshirpour, Farhad, Patel, Mihir, Hart, Craig F, Drake, Amelia F
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antineoplastic Agents, Phytogenic - therapeutic use
Child, Preschool
Cyclophosphamide - therapeutic use
Dactinomycin - therapeutic use
Humans
Male
Maxillary Neoplasms - drug therapy
Maxillary Neoplasms - pathology
Maxillary Neoplasms - surgery
Myeloablative Agonists - therapeutic use
Myofibromatosis - drug therapy
Myofibromatosis - pathology
Myofibromatosis - surgery
Remission Induction
Vincristine - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infantile myofibromatosis is a rare proliferative mesenchymal disorder that has a potential for rapid growth and recurrence. Approximately 30% of infantile myofibromatosis lesions present in the head and neck, and some of these can cause significant morbidity. We report a case of recurrent infantile myofibromatosis that persisted after surgery and chemotherapy and was managed conservatively. Treatment of infantile myofibromatosis varies according to the size, location, and extent of disease. Solitary lesions may be simply observed in view of their potential for regression, but surgical excision, radiotherapy, and/or chemotherapy should be considered on a case-by-case basis, especially for nonresectable, rapidly progressive, or symptomatic lesions.
ISSN:1942-7522