DOUBLE-BLIND COMPARISON OF THE MORPHINE SPARING EFFECT OF CONTINUOUS AND INTERMITTENT I.M. ADMINISTRATION OF KETOROLAC

The morphine sparing effect of ketorolac 10 mg administered 4-hourly by intermittent i.m. injection was compared with a continuous i.m. infusion in a double-blind, placebo-controlled trial in patients undergoing upper abdominal surgery. During the 48-h postoperative period, each patient was provided...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1991-09, Vol.67 (3), p.235-238
Main Authors: BURNS, J.W., AITKEN, H.A., BULLINGHAM, R.E.S., MCARDLE, C.S., KENNY, G.N.C.
Format: Article
Language:English
Subjects:
Abdomen - surgery
Adolescent
Adult
Aged
Analgesia, Patient-Controlled
Analgesia:postoperative
Analgesics
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Biological and medical sciences
Double-Blind Method
gesics: ketorolac
Humans
Infusions, Parenteral
Injections, Intramuscular
Ketorolac
Medical sciences
Middle Aged
morphine
Morphine - administration & dosage
Morphine - adverse effects
Neuropharmacology
Pain Measurement
Pain, Postoperative - drug therapy
PCAS
Pharmacology. Drug treatments
Tolmetin - administration & dosage
Tolmetin - adverse effects
Tolmetin - analogs & derivatives
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Summary:The morphine sparing effect of ketorolac 10 mg administered 4-hourly by intermittent i.m. injection was compared with a continuous i.m. infusion in a double-blind, placebo-controlled trial in patients undergoing upper abdominal surgery. During the 48-h postoperative period, each patient was provided with a patientcontrolled analgesia (PCA) system which delivered bolus doses of morphine and administered the intermittent i.m. doses automatically via a computer controlled pump. In the first 24 h after surgery, there was a significant reduction in morphine demanded by both groups receiving ketorolac compared with placebo. Patients who received a continuous infusion of ketorolac after abdominal surgery required a median dose of morphine by PCA which was 49% less than controls. In the second 24 h and over the entire 48 h of the study, patients in the continuous group required significantly less morphine than those in the placebo group. The intermittent group used less than the placebo group, but this was not significant.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/67.3.235