Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements

Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has t...

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Bibliographic Details
Published in:Applied optics. Optical technology and biomedical optics 2009-02, Vol.48 (4), p.B73
Main Authors: Parameswaran, Krishnan R, Rosen, David I, Allen, Mark G, Ganz, Alan M, Risby, Terence H
Format: Article
Language:English
Subjects:
Breath Tests - instrumentation
Breath Tests - methods
Equipment Design
Equipment Failure Analysis
Ethane - analysis
Humans
Lasers
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry, Infrared - instrumentation
Spectrophotometry, Infrared - methods
Systems Integration
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Summary:Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off-axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48 ppb/Hz(1/2).
ISSN:2155-3165
DOI:10.1364/AO.48.000B73