Validation of the folate food frequency questionnaire with serum and erythrocyte folate and plasma homocysteine

The aim of the present study was to develop and validate a folate food frequency questionnaire (FFQ)1 designed to measure dietary folate equivalents. The self-administered FFQ containing 39 items and a reference period of 1 month (i.e. the previous month), was validated against three biomarkers: ser...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2009-01, Vol.60 (s5), p.10-18
Main Authors: Bari, Irena Coli, Šatali, Zvonimir, Keser, Irena, Ceci, Ivana, Su i, Martina
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers - blood
Body Mass Index
Correlation analysis
Croatia
Diet
Diet Surveys
dietary folate equivalents
Discriminant analysis
Erythrocytes
Erythrocytes - chemistry
Female
folate
Folic Acid - administration & dosage
Folic Acid - blood
Folic Acid Deficiency - blood
Folic Acid Deficiency - diagnosis
Folic Acid Deficiency - epidemiology
Food frequency questionnaire
Food science
homocysteine
Homocysteine - blood
Humans
Middle Aged
Nutritional Status
Plasma
Principal Component Analysis
Surveys and Questionnaires
Vitamin B
Young Adult
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Summary:The aim of the present study was to develop and validate a folate food frequency questionnaire (FFQ)1 designed to measure dietary folate equivalents. The self-administered FFQ containing 39 items and a reference period of 1 month (i.e. the previous month), was validated against three biomarkers: serum and erythrocyte (RBC) folate, and plasma homocysteine (Hcy). Subjects were women (n=99) between the ages of 21 and 87 years. The Pearson correlation coefficients for folate intake and biomarkers were 0.36, 0.34 and −0.25 for serum and RBC folate, and plasma Hcy, respectively. A principal component factor analysis was performed on the three biomarkers to calculate the folate status factor. The Pearson correlation for the folate status factor and folate intake was 0.39. The FFQ described in this study is a valid tool for measuring folate intake expressed as dietary folate equivalents in adult women and is suitable for future investigations about the relationship between folate and disease, or as an educational tool.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637480802249074