EXPOSURE TO ENVIRONMENTAL TOBACCO SMOKE INDUCES ANGIOGENESIS AND LEUKOCYTE TRAFFICKING IN LUNG MICROVESSELS

Exposure to environmental tobacco smoke (ETS) is known to contribute to and exacerbate inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) and asthma. The effect of ETS on angiogenesis and leukocyte recruitment, both of which promote lung inflammation, was investig...

Full description

Saved in:
Bibliographic Details
Published in:Experimental lung research 2009-03, Vol.35 (2), p.119-135
Main Authors: Rao, Savita P., Sikora, Lyudmila, Hosseinkhani, M. Reza, Pinkerton, Kent E., Sriramarao, P.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Chemotaxis, Leukocyte
environmental tobacco smoke
Inflammation - etiology
Inflammation - pathology
Leukocyte Rolling
leukocyte trafficking
Leukocytes - pathology
Lung - blood supply
lung angiogenesis
Mice
Microvessels - immunology
Neovascularization, Pathologic
Neutrophils - pathology
nicotine
Tobacco Smoke Pollution - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exposure to environmental tobacco smoke (ETS) is known to contribute to and exacerbate inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) and asthma. The effect of ETS on angiogenesis and leukocyte recruitment, both of which promote lung inflammation, was investigated using lung tissue from mice exposed to aged and diluted sidestream cigarette smoke or fresh air for 12 weeks and transplanted into dorsal skin-fold chambers in nude mice. Lung tissue from mice exposed to cigarette smoke for 12 weeks exhibited significantly increased vascular density (angiogenesis) associated with selectin-mediated increased intravascular leukocyte rolling and adhesion compared to fresh air-exposed lung tissue by intravital microscopy. Further, neutrophils from nicotine-exposed mice displayed significantly increased rolling and adhesion compared to control neutrophils in microvessels of nicotine-exposed lungs versus control lung microvessels, suggesting that nicotine in cigarette smoke can augment leukocyte-endothelial interactions. ETS-induced angiogenesis and leukocyte trafficking may play a key role in airway recruitment of inflammatory cells in ETS-associated disorders such as COPD bronchitis or asthma.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140802449729