Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient

Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic pati...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-07, Vol.47 (7), p.2328-2331
Main Authors: Schoen, Christoph, Unzicker, Christian, Stuhler, Gernot, Elias, Johannes, Einsele, Hermann, Grigoleit, Götz Ulrich, Abele-Horn, Marianne, Mielke, Stephan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteriology
Biological and medical sciences
Case Reports
Cord Blood Stem Cell Transplantation - adverse effects
Corynebacterium - drug effects
Corynebacterium - isolation & purification
Corynebacterium Infections - microbiology
Corynebacterium jeikeium
Daptomycin - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Leukemia, Myeloid, Acute - complications
Male
Microbial Sensitivity Tests
Microbiology
Middle Aged
Miscellaneous
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Summary:Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic patient undergoing cord blood transplantation for secondary acute myeloid leukemia.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00457-09