Gene Expression Profiling of ErbB Receptors and Ligands in Human Meningiomas

ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of life. Tumor therapy requires information about molec...

Full description

Saved in:
Bibliographic Details
Published in:Cancer investigation 2009-01, Vol.27 (6), p.691-698
Main Authors: Laurendeau, Ingrid, Ferrer, Marcela, Garrido, Delia, D'Haene, Nicky, Ciavarelli, Patricia, Basso, Armando, Vidaud, Michel, Bieche, Ivan, Salmon, Isabelle, Szijan, Irene
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amphiregulin
Betacellulin
EGF Family of Proteins
Epidermal Growth Factor - genetics
Epigen
ErbB receptors
Female
Gene expression
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Genes, erbB
Glycoproteins - genetics
Heparin-binding EGF-like Growth Factor
Humans
Intercellular Signaling Peptides and Proteins - genetics
Ligands
Male
Meningeal Neoplasms - genetics
Meningeal Neoplasms - pathology
Meningioma - genetics
Meningioma - pathology
Meningiomas
Middle Aged
Neoplasm Staging
Neuregulins - genetics
Polymerase Chain Reaction
Receptor, Epidermal Growth Factor - genetics
Receptor, ErbB-2 - genetics
Receptor, ErbB-4
RNA, Messenger - metabolism
Transforming Growth Factor alpha - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of life. Tumor therapy requires information about molecular alterations, thus we studied expression of ErbB receptor and ligand genes by real-time RT-PCR in different meningioma grades. Receptors were overexpressed (ErbB1, ErbB2) or underexpressed (ErbB3, ErbB4). Ligands EGF, TGFA, AREG, DTR, BTD were underexpressed and the neuregulins were overexpressed or underexpressed. A strong ErbB1-ErbB2 correlation was found. These data might be useful for gene therapy.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357900802709175