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Sequence selective formation of 1,N(6)-ethenoadenine in DNA by furan-conjugated probe
1,N(6)-Ethenoadenosine derivatives have been applied as fluorescence probes in various fields of biochemistry and molecular biology. We developed a 1,N(6)-ethenoadenosine-forming reaction at a target adenine in DNA duplex and applied it to a mutation diagnosis. Furan-derivatized oligodeoxyribonucleo...
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| Published in: | Bioorganic & medicinal chemistry letters 2009-07, Vol.19 (13), p.3657 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_issue | 13 |
| container_start_page | 3657 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 19 |
| creator | Kobori, Akio Morita, Jumpei Ikeda, Masato Yamayoshi, Asako Murakami, Akira |
| description | 1,N(6)-Ethenoadenosine derivatives have been applied as fluorescence probes in various fields of biochemistry and molecular biology. We developed a 1,N(6)-ethenoadenosine-forming reaction at a target adenine in DNA duplex and applied it to a mutation diagnosis. Furan-derivatized oligodeoxyribonucleotides were synthesized and fluorescence properties were studied in the presence of complementary strand under oxidative conditions. Strong emissions at 430nm were observed in the presence of the complementary strand with an adenine in front of furan moiety. |
| doi_str_mv | 10.1016/j.bmcl.2009.04.092 |
| format | article |
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| fulltext | fulltext |
| identifier | EISSN: 1464-3405 |
| ispartof | Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3657 |
| issn | 1464-3405 |
| language | eng |
| recordid | cdi_pubmed_primary_19464174 |
| source | ScienceDirect Journals |
| subjects | Adenine - analogs & derivatives Adenine - analysis Adenine - chemistry Adenosine - analogs & derivatives Adenosine - chemistry Base Sequence DNA - chemistry DNA Adducts - analysis DNA Probes - chemistry Fluorescent Dyes - chemistry Furans - chemistry Mutation Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Oxidation-Reduction |
| title | Sequence selective formation of 1,N(6)-ethenoadenine in DNA by furan-conjugated probe |
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