Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats

Background: In this study, nanosuspension was prepared to improve the dissolution rate and bioavailability of lipophilic fenofibrate. Method: Melt emulsification method combined with high-pressure homogenization was adapted, and mixture of poloxamer188 and PVP K30 were selected as surfactants. This...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2009-07, Vol.35 (7), p.827-833
Main Authors: Li, XueMing, Gu, Li, Xu, YuanLong, Wang, YongLu
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Fenofibrate
Fenofibrate - chemical synthesis
Fenofibrate - pharmacokinetics
General pharmacology
high-pressure homogenization
Male
Medical sciences
melt emulsification
Nanoparticles - chemistry
nanosuspension
Pharmaceutical technology. Pharmaceutical industry
pharmacokinetic
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Suspensions
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Summary:Background: In this study, nanosuspension was prepared to improve the dissolution rate and bioavailability of lipophilic fenofibrate. Method: Melt emulsification method combined with high-pressure homogenization was adapted, and mixture of poloxamer188 and PVP K30 were selected as surfactants. This method consumed less energy and was more efficient than traditional homogenization of drug solid particles suspension directly. Results: The dissolution rate of fenofibrate nanosuspension was increased obviously, and the product was evaluated by pharmacokinetic characteristic in rats. The AUC0-36 h and Cmax of nanosuspensions were increased when compared with the reference formulations. No significant differences were found between the two nanosuspensions A and B, of which the mean particle sizes were 356 and 194 nm, respectively. Therefore, nanosuspensions may be a suitable delivery system to improve the bioavailability of those drugs with poor water solubility.
ISSN:0363-9045
1520-5762
DOI:10.1080/03639040802623941