Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves

Lysophosphatidic acid (LPA) is a lipid mediator that plays a role in the process of wound healing in animal tissues, including the digestive tract. We determined LPA in several foodstuffs, and found that cabbage leaves were the richest source of LPA. We also found that, at 22 and 195 nmol/g (wet wei...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-06, Vol.73 (6), p.1293-1300
Main Authors: Tanaka, T.(Fukuyama Univ., Hiroshima (Japan). Faculty of Life Science and Biotechnology), Horiuchi, G, Matsuoka, M, Hirano, K, Tokumura, A, Koike, T, Satouchi, K
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biological and medical sciences
Brassica
Brassica - metabolism
cabbage
CABBAGES
Cell Proliferation - drug effects
CHOU POMME
CURACION
digestive tract
EXTRACTOS
EXTRACTS
EXTRAIT
FEUILLE
FIBROBLASTE
FIBROBLASTOS
FIBROBLASTS
FOSFOLIPIDOS
Fundamental and applied biological sciences. Psychology
GUERISON
HEALING
HERIDAS
HOJAS
LEAVES
LIPIDE
LIPIDOS
LIPIDS
lysophosphatidic acid
Lysophospholipids - biosynthesis
Lysophospholipids - pharmacology
Mastication
Mice
MILLING
MOLIENDA
MOUTURE
NEOPLASMAS
NEOPLASME
NEOPLASMS
PHOSPHATIDE
PHOSPHOLIPIDS
PLAIE
Plant Leaves - metabolism
REPOLLO
wound healing
Wound Healing - drug effects
WOUNDS
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Summary:Lysophosphatidic acid (LPA) is a lipid mediator that plays a role in the process of wound healing in animal tissues, including the digestive tract. We determined LPA in several foodstuffs, and found that cabbage leaves were the richest source of LPA. We also found that, at 22 and 195 nmol/g (wet weight), LPA and phosphatidic acid (PA) were respectively formed during mastication of raw cabbage leaves and that the resulting PA was converted to LPA by pancreatic phospholipase A 2 . The lipid extract obtained from ground cabbage leaves promoted the proliferation of Swiss 3T3 fibroblasts and the motility of HGC-27 cells, stomach-derived epithelial-like cells, at physiologically relevant concentrations. These activities of cabbage lipids were inhibited by Ki16425, an LPA-receptor antagonist. LPA formed during the digestion of cabbage leaves may be one of the components in the beneficial effect of ingested cabbage on a damaged digestive tract.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.80813