Autoimmune bullous dermatoses

Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2009-03, Vol.84 (2), p.111
Main Authors: Cunha, Paulo R, Barraviera, Silvia Regina C S
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmune Diseases - therapy
Dermatitis Herpetiformis - immunology
Dermatitis Herpetiformis - pathology
Dermatitis Herpetiformis - therapy
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Humans
Immunoblotting
Pemphigoid, Bullous - immunology
Pemphigoid, Bullous - pathology
Pemphigoid, Bullous - therapy
Pemphigus - immunology
Pemphigus - pathology
Pemphigus - therapy
Skin Diseases, Vesiculobullous - immunology
Skin Diseases, Vesiculobullous - pathology
Skin Diseases, Vesiculobullous - therapy
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Summary:Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire), pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis.
ISSN:1806-4841