Sulfasalazine-induced hypersensitivity syndrome in a 15-year-old boy associated with human herpesvirus-6 reactivation

Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DIHS and has prognostic importance. We report a 15-year-old boy...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2009-03, Vol.28 (1), p.45-47
Main Authors: Balci, Didem Didar, Peker, Erdal, Duran, Nizami, Dogramaci, Cigdem Asena
Format: Article
Language:English
Subjects:
Adolescent
Antirheumatic Agents - adverse effects
Arthritis, Juvenile - complications
Arthritis, Juvenile - drug therapy
Biological and medical sciences
Drug Eruptions - etiology
Drug toxicity and drugs side effects treatment
drug-induced hypersensitivity syndrome
Herpesvirus 6, Human - drug effects
Herpesvirus 6, Human - immunology
Human herpesvirus 6
human herpesvirus-6 reactivation
Humans
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Roseolovirus Infections - complications
Sulfasalazine
Sulfasalazine - adverse effects
Toxicology
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Summary:Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DIHS and has prognostic importance. We report a 15-year-old boy with juvenile rheumatoid arthritis who developed DIHS due to sulfasalazine, associated with reactivation of HHV-6.
ISSN:1556-9527
1556-9535
DOI:10.1080/15569520802696250