Effects of natamycin on sister chromatid exchanges, chromosome aberrations and micronucleus in human lymphocytes

• Published in: Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2009, Vol.32 (1), p.47-52
• Main Authors: Rencüzo ullari, Eyyüp, Azirak, Sebile, Canimoglu, Semir, Parlak, Sebnem, Buyukleyla, Mehmet
• Format: Article
• Language: English
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - administration & dosage; Antifungal Agents - toxicity; Biological and medical sciences; Chromosome aberration; Chromosome Aberrations - drug effects; Dose-Response Relationship, Drug; Female; Human lymphocytes; Humans; Lymphocytes - drug effects; Male; Medical sciences; Micronuclei, Chromosome-Defective - chemically induced; Micronucleus; Micronucleus Tests; Natamycin; Natamycin - administration & dosage; Natamycin - toxicity; Pharmacology. Drug treatments; Sister chromatid exchange; Sister Chromatid Exchange - drug effects; Time Factors; Young Adult
• ISSN: 0148-0545; 1525-6014
• DOI: 10.1080/01480540802431371

Natamycin (pimaricin) (E235) is an antifungal that can be used as an antibiotic to treat most fungus infections. It has been globally used in a variety of foods and beverages. In the present study, the effects of natamycin on chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) formation in human lymphocytes cells were investigated. The human lymphocytes were treated with 13, 18, 23, and 28 μg/mL of natamycin for 24 and 48 h. Natamycin induced the SCE frequency at the highest concentration for 48 h only; however, it induced the structural CA and MN frequency at all concentrations when compared to control and at all concentrations, except the lowest concentration (13 μg/mL), when compared to solvent control. Natamycin showed a cytotoxic effect by decreasing the replication index, mitotic index, and nuclear division index (NDI), especially at the highest concentrations for two treatment periods.