Serum procollagen type III is associated with elevated right-sided filling pressures in stable outpatients with congestive heart failure

Elevated filling pressures are associated with heart failure deterioration, but mechanisms underlying this association remain poorly understood. We sought to investigate whether or not elevated filling pressures are associated with increased collagen turnover, evaluated by procollagen type III amino...

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Bibliographic Details
Published in:Biomarkers 2009-09, Vol.14 (6), p.438-442
Main Authors: Biolo, Andréia, Rohde, Luis E., Goldraich, Livia A., Mascarenhas, Marcello, Palombini, Dora V., Clausell, Nadine
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Pressure
Cardiology. Vascular system
Collagen Type III - blood
Congestive heart failure
Electrocardiography
Extracellular Matrix - metabolism
Female
filling pressures
haemodynamics
Heart
Heart Atria - physiopathology
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics
Humans
Male
Medical sciences
Middle Aged
Outpatients
procollagen type III
remodelling
Toxicology
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Summary:Elevated filling pressures are associated with heart failure deterioration, but mechanisms underlying this association remain poorly understood. We sought to investigate whether or not elevated filling pressures are associated with increased collagen turnover, evaluated by procollagen type III aminoterminal peptide (PIIINP) levels, in stable systolic heart failure. Eighty patients with heart failure with severe systolic dysfunction (ejection fraction 26 ± 7%) were included. Patients underwent simultaneous echocardiogram with evaluation of haemodynamic parameters and blood sampling for PIIINP measurement. Mean PIIINP level was 6.11 ± 2.62 μg l−1. PIIINP was positively associated with estimated right atrial pressure (RAP) (r = 0.36; p = 0.001). Mean PIIINP values were 5.04 ± 2.42 μg l−1 in patients with estimated RAP ≤ 5 mmHg, and 7.59 ± 2.54 μg l−1 in those with RAP > 15 mmHg (p 
ISSN:1354-750X
1366-5804
DOI:10.1080/13547500903098293