The Mammalian Urine Concentrating Mechanism: Hypotheses and Uncertainties

Anita T. Layton 1 , Harold E. Layton 1 , William H. Dantzler 2 and Thomas L. Pannabecker 2 1 Department of Mathematics, Duke University, Durham, North Carolina; and 2 Department of Physiology, College of Medicine, University of Arizona, Tuscon, Arizona, alayton{at}math.duke.edu The urine concentrati...

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Published in:Physiology (Bethesda, Md.) Md.), 2009-08, Vol.24 (4), p.250-256
Main Authors: Layton, Anita T, Layton, Harold E, Dantzler, William H, Pannabecker, Thomas L
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - physiology
Kidney Medulla - blood supply
Kidney Medulla - physiology
Kidney Tubules - blood supply
Kidney Tubules - physiology
Loop of Henle - blood supply
Loop of Henle - physiology
Models, Animal
Rats
Urine - physiology
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Summary:Anita T. Layton 1 , Harold E. Layton 1 , William H. Dantzler 2 and Thomas L. Pannabecker 2 1 Department of Mathematics, Duke University, Durham, North Carolina; and 2 Department of Physiology, College of Medicine, University of Arizona, Tuscon, Arizona, alayton{at}math.duke.edu The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney’s three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00013.2009