Preparation and characterization of Vitamin-12 loaded biodegradable pH-sensitive microgels

This paper prepared novel biodegradable and pH-sensitive microgels based on Poly( -caprolactone)-Pluronic-Poly( -caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by...

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Bibliographic Details
Published in:Journal of microencapsulation 2009-11, Vol.26 (7), p.642-648
Main Authors: Xu, Xu, Fu, ShaoZhi, Wang, Ke, Jia, WenJuan, Guo, Gang, Zheng, XiuLing, Dong, PengWei, Guo, QingFa, Qian, ZhiYong
Format: Article
Language:English
Subjects:
biodegradable polymer
Biological and medical sciences
Gels
General and cellular metabolism. Vitamins
General pharmacology
hydrogel
Hydrogen-Ion Concentration
Medical sciences
Methacrylates - chemistry
microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Poloxalene - analogs & derivatives
Poloxalene - chemistry
Polyesters - chemistry
Polyethylene Glycols - chemistry
polymeric drug delivery system
Smart material (pH sensitive)
Vitamin B 12 - administration & dosage
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Summary:This paper prepared novel biodegradable and pH-sensitive microgels based on Poly( -caprolactone)-Pluronic-Poly( -caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by NaHSO3, K2S2O8. The blank microgels were prepared by inversed-phase suspension polymerization method and pH sensitivity of microgels was characterized. Then the blank microgels were loaded with hydrophilic model drug vitamin-12 (VB-12) and in vitro drug release behaviour was also studied here.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652040802610827