Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells

• Published in: Molecular and Cellular Biology 2010-02, Vol.30 (3), p.694-710
• Main Authors: Adon, Arsene M., Zeng, Xiangbin, Harrison, Mary K., Sannem, Stacy, Kiyokawa, Hiroaki, Kaldis, Philipp, Saavedra, Harold I.
• Format: Article
• Language: English
• Subjects: Animals; Cell Cycle - physiology; Cell Line; Centrioles - metabolism; Centrosome - metabolism; Chromosomal Instability - genetics; Chromosomal Instability - physiology; Cyclin-Dependent Kinase 2 - genetics; Cyclin-Dependent Kinase 2 - metabolism; Cyclin-Dependent Kinase 4 - genetics; Cyclin-Dependent Kinase 4 - metabolism; Fibroblasts - cytology; Fibroblasts - metabolism; Gene Knockout Techniques; Mice; Nuclear Proteins - metabolism; Phosphorylation - physiology; RNA, Small Interfering - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.00253-09

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