Blood Serum Levels of Amino-Terminal Pro-C-Type Natriuretic Peptide in Patients with Systemic Sclerosis

The aim of this pilot study was to examine the association of serum levels of amino-terminal fragment of pro-C-type natriuretic peptide (NT-proCNP), as a substitute measure of serum C-type natriuretic peptide (CNP), with clinical and laboratory findings in patients with systemic sclerosis (SSc). Ser...

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Bibliographic Details
Published in:Connective tissue research 2010-04, Vol.51 (2), p.83-87
Main Authors: Olewicz-Gawlik, Anna, Danczak-Pazdrowska, Aleksandra, Klama, Kamilla, Silny, Wojciech, Prokop, Janusz, Mackiewicz, Stefan, Grala, Pawel, Hrycaj, Pawel
Format: Article
Language:English
Subjects:
Biomarkers - blood
C-Reactive Protein - analysis
C-type Natriuretic Peptide
Disease Progression
E-Selectin - blood
Endothelium
Female
Health Status
Humans
Inflammation
Male
Middle Aged
Natriuretic Peptide, C-Type - blood
P-Selectin - blood
Pilot Projects
Scleroderma, Systemic - blood
Scleroderma, Systemic - pathology
Scleroderma, Systemic - physiopathology
Selectins
Severity of Illness Index
Skin - pathology
Systemic Sclerosis
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Summary:The aim of this pilot study was to examine the association of serum levels of amino-terminal fragment of pro-C-type natriuretic peptide (NT-proCNP), as a substitute measure of serum C-type natriuretic peptide (CNP), with clinical and laboratory findings in patients with systemic sclerosis (SSc). Serum NT-proCNP, soluble (s)E-and sP-selectin levels were examined using specific enzyme-linked immunosorbent assay in 30 patients with SSc and 30 healthy controls. We found no statistically significant difference in serum levels of NT-proCNP neither between patients with SSc and healthy controls nor between those treated with immunosuppressive agents and untreated patients. Nevertheless, in the investigated SSc group, serum NT-proCNP levels correlated with the concentrations of C-reactive protein (CRP) and the duration of the disease. Both sP- and sE-selectin levels were elevated in SSc patients when compared to healthy subjects. Also they did not correlate with the concentrations of NT-proCNP. The results of the study indicate that serum NT-proCNP level is likely secondary to existing inflammation. However, the magnitude of CNP action in SSc and its possible role in the pathogenesis of the disease remains to be elucidated.
ISSN:0300-8207
1607-8438
DOI:10.3109/03008200903056168