Seizure and non-cardiogenic pulmonary edema after intoxication

We report a case of severe intoxication with extended-release verapamil. In addition to cardiovascular toxicities with hypotension, atrioventricular block and bradycardia, the patient suffered from grand-mal seizure and pulmonary edema 13 and 48 hours respectively, after ingestion of 4.8 g of extend...

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Bibliographic Details
Published in:Der Internist (Berlin) 2010-04, Vol.51 (4), p.528
Main Authors: Sawatzki, M, Kummer, O, Krähenbühl, S, Siegemund, M
Format: Article
Language:ger
Subjects:
Adult
Cardiovascular Diseases - complications
Diagnosis, Differential
Female
Humans
Pulmonary Edema - chemically induced
Pulmonary Edema - diagnosis
Seizures - chemically induced
Seizures - diagnosis
Verapamil - toxicity
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Summary:We report a case of severe intoxication with extended-release verapamil. In addition to cardiovascular toxicities with hypotension, atrioventricular block and bradycardia, the patient suffered from grand-mal seizure and pulmonary edema 13 and 48 hours respectively, after ingestion of 4.8 g of extended-release verapamil. Adverse reactions after intoxications with extended-release tablets appear delayed with prolonged manifestation of symptoms. Early and repetitive administration of activated charcoal and antegrade whole bowel lavage are crucial, even in primary asymptomatic patients.
ISSN:1432-1289
DOI:10.1007/s00108-009-2544-2