A new antibacterial compound from Luo Han Kuo fruit extract (Siraitia grosvenori)

Luo Han Kuo fruit (Siraitia grosvenori Swingle) has been used in China for centuries as a sweetening agent, and also used to treat sore throat and cough. In our recent study, a new bioactive compound, (2R,3S,4S)-2,3-trans-3,4-cis-5,3′-bimethoxy-7-(trans-2-propenal)-3,4-flavandiol (1), named siraitif...

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Bibliographic Details
Published in:Journal of asian natural products research 2009-08, Vol.11 (8), p.761-765
Main Authors: Zheng, Yan, Liu, Zhonglian, Ebersole, Jeff, Huang, Chifu Brad
Format: Article
Language:English
Subjects:
(2R,3S,4S)-2,3-trans-3,4-cis-5,3′-bimethoxy-7-(trans-2-propenal)-3,4-flavandiol
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteria
Bacteriology
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Flavonols - chemistry
Flavonols - isolation & purification
Flavonols - pharmacology
Fruit - chemistry
General pharmacology
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Natural products
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Porphyromonas gingivalis
Porphyromonas gingivalis - drug effects
Siraitia grosvenori Swingle
Streptococcus mutans
Streptococcus mutans - drug effects
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Summary:Luo Han Kuo fruit (Siraitia grosvenori Swingle) has been used in China for centuries as a sweetening agent, and also used to treat sore throat and cough. In our recent study, a new bioactive compound, (2R,3S,4S)-2,3-trans-3,4-cis-5,3′-bimethoxy-7-(trans-2-propenal)-3,4-flavandiol (1), named siraitiflavandiol was obtained. The structure has been determined on the basis of spectroscopic studies including 1D and 2D NMR ( 1 H, 13 C NMR, 1 H- 1 H COSY, HSQC, HMBC, and NOESY), CD, EI-MS, and HR-EI-MS spectra. The new compound was evaluated in vitro for its inhibitory ability against the growth of oral bacterial species Streptococcus mutans, Porphyromonas gingivalis, and yeast Candida albicans. The minimum inhibitory concentrations were 6, 24, and 6 μg/ml, respectively.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020903048983