Altered Brain Myelin Sheath Morphology after Rewarming in Situ

In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantifie...

Full description

Saved in:
Bibliographic Details
Published in:Ultrastructural pathology 2010, Vol.34 (2), p.82-89
Main Authors: Dietrichs, E. S., Lindal, S., Naesheim, T., Ingebrigtsen, T., Tveita, T.
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Brain Injuries - etiology
Brain Injuries - metabolism
Brain Injuries - pathology
Cerebrum - metabolism
Cerebrum - pathology
Cerebrum - physiopathology
Disease Models, Animal
Hemodynamics
hypothermia
Hypothermia, Induced - adverse effects
Male
Microscopy, Electron, Transmission
myelin damage
Myelin Sheath - ultrastructure
Nerve Growth Factors - metabolism
Rats
Rats, Wistar
Rewarming
S100 Calcium Binding Protein beta Subunit
S100 Proteins - metabolism
ultra structure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13°C). Animals held at 37°C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100β was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p
ISSN:0191-3123
1521-0758
DOI:10.3109/01913120903398753