The Brucella abortus Phosphoglycerate Kinase Mutant Is Highly Attenuated and Induces Protection Superior to That of Vaccine Strain 19 in Immunocompromised and Immunocompetent Mice

• Published in: Infection and Immunity 2010-05, Vol.78 (5), p.2283-2291
• Main Authors: TRANT, Cyntia G. M. C, LACERDA, Thais L. S, CARVALHO, Natalia B, AZEVEDO, Vasco, ROSINHA, Gracia M. S, SALCEDO, Suzana P, GORVEL, Jean-Pierre, OLIVEIRA, Sergio C
• Format: Article
• Language: English
• Subjects: Abortion; Animals; Bacterial Proteins; Bacterial Proteins - genetics; Bacteriology; Biological and medical sciences; Bone marrow; Brucella abortus; Brucella abortus - enzymology; Brucella abortus - immunology; Brucella abortus - pathogenicity; Brucella Vaccine; Brucella Vaccine - genetics; Brucella Vaccine - immunology; Brucellosis; Brucellosis - immunology; Brucellosis - prevention & control; Cells, Cultured; Colony Count, Microbial; Deletion mutant; DNA, Bacterial; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; Domestic animals; Female; Fever; Fundamental and applied biological sciences. Psychology; Gene Deletion; Humans; Immunity; Immunology; Interferon regulatory factor 1; Life Sciences; Macrophages; Macrophages - microbiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbial Immunity and Vaccines; Microbiology; Miscellaneous; Molecular Sequence Data; Pathogens; Phosphoglycerate Kinase; Phosphoglycerate Kinase - deficiency; Recombination; Sequence Analysis, DNA; Spleen; Spleen - microbiology; Survival Analysis; Vaccines; Vaccines, Attenuated; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vacuoles; virulence factors; Western blotting
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.01433-09

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