Monoclonal antibodies used as prophylactic, therapeutic and diagnostic agents

Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. The preparation, mechanism of action, uses, and possible adverse effects of...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2010-12, Vol.32 (4), p.533-542
Main Authors: Chakhtoura, Marita, Abdelnoor, Alexander M.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - biosynthesis
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
drawbacks
Humans
Immunotoxins - adverse effects
Immunotoxins - chemistry
Immunotoxins - therapeutic use
mechanism of action
Monoclonal antibodies
preparation
uses
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Description
Summary:Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. The preparation, mechanism of action, uses, and possible adverse effects of most of the available monoclonal antibodies used as prophylactic, therapeutic, and diagnostic agents are reviewed.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923971003646597