Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model

• Published in: Antimicrobial Agents and Chemotherapy 2010-05, Vol.54 (5), p.2051-2062
• Main Authors: BULITTA, Jürgen B, YANG, Jenny C, YOHONN, Liliana, LY, Neang S, BROWN, Silvia V, D'HONDT, Rebecca E, JUSKO, William J, FORREST, Alan, TSUJI, Brian T
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria; Bacterial Outer Membrane Proteins - metabolism; Binding, Competitive; Biological and medical sciences; Calcium - metabolism; Colistin; Colistin - pharmacokinetics; Drug Resistance, Bacterial; Experimental Therapeutics; In Vitro Techniques; Magnesium - metabolism; Medical sciences; Microbial Sensitivity Tests; Models, Biological; Pharmacology. Drug treatments; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - growth & development; Pseudomonas aeruginosa - metabolism
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00881-09

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