Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers

The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe e...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1991-05, Vol.36 (5), p.594
Main Authors: Stadler, P, Armstrong, D, Margalith, D, Saraga, E, Stolte, M, Lualdi, P, Mautone, G, Blum, A L
Format: Article
Language:English
Subjects:
Adult
Candidiasis - chemically induced
Diclofenac - adverse effects
Double-Blind Method
Duodenoscopy
Duodenum - drug effects
Duodenum - pathology
Esophageal Diseases - chemically induced
Esophagoscopy
Female
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Gastroscopy
Humans
Male
Middle Aged
Pain - chemically induced
Reference Values
Wound Healing - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe endoscopic lesions (petechiae, erosions, ulcers, and esophageal candidiasis) were found only in the group taking the soluble formulation of diclofenac (P less than 0.05 vs placebo). The endoscopic healing of biopsies at one week was delayed by both preparations in comparison to placebo (P less than 0.05 vs placebo). Neither formulation produced significantly more histological inflammation or minor endoscopic lesions (erythema, red striae) than placebo. Both formulations were equally well tolerated and produced no more symptoms than placebo. This study suggests that soluble diclofenac acts topically to delay gastroduodenal healing and produce gastroduodenal injury; it thus provides a model for future studies of the production, perpetuation, and healing of peptic lesions.
ISSN:0163-2116
DOI:10.1007/BF01297025