Catastrophic rapid onset heparin-induced thrombocytopenia - Victim of our own success

Heparin is integral to the treatment of acute coronary syndromes, deep vein thrombosis and its prophylaxis. An undesirable result of recurrent heparin use is rapid onset heparin-induced thrombocytopenia (HIT) within hours of exposure.This catastrophic condition is frequently diagnosed too late for t...

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Bibliographic Details
Published in:Acta Cardiologica 2010-02, Vol.65 (1), p.93-95
Main Authors: Nanda, Sudip, Sharma, Shree Gopal, Longo, Santo
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Diagnosis, Differential
Disease Progression
Fatal Outcome
Follow-Up Studies
Heparin - adverse effects
Heparin - therapeutic use
Heparin-induced thrombocytopenia
Humans
Male
Platelet Count
rapid onset HIT
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnosis
Thromboembolism - drug therapy
Time Factors
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Summary:Heparin is integral to the treatment of acute coronary syndromes, deep vein thrombosis and its prophylaxis. An undesirable result of recurrent heparin use is rapid onset heparin-induced thrombocytopenia (HIT) within hours of exposure.This catastrophic condition is frequently diagnosed too late for therapy to be effective.We describe a case of fatal rapid onset HIT, analyze current evidence to diagnose this condition and propose a way so that it can be prevented.
ISSN:0001-5385
1784-973X
0001-5385
DOI:10.2143/AC.65.1.2045897