Histopathological diagnosis and differential diagnosis of colorectal serrated polys: findings of a consensus conference of the working group "gastroenterological pathology of the German Society of Pathology"

• Main Authors: Baretton, G B, Autschbach, F, Baldus, S, Bläker, H, Faller, G, Koch, H K, Langner, C, Lüttges, J, Neid, M, Schirmacher, P, Tannapfel, A, Vieth, M, Aust, D E
• Format: Conference Proceeding
• Language: ger
• Subjects: Adenoma - diagnosis; Adenoma - genetics; Adenoma - pathology; Adenoma - therapy; Apoptosis - genetics; Biopsy; Cell Division - genetics; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - pathology; Colonic Polyps - diagnosis; Colonic Polyps - genetics; Colonic Polyps - pathology; Colonic Polyps - therapy; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; CpG Islands - genetics; Diagnosis, Differential; DNA Methylation - genetics; Epigenesis, Genetic - genetics; Genetic Markers - genetics; Humans; Hyperplasia; Intestinal Mucosa - pathology; Precancerous Conditions - diagnosis; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Precancerous Conditions - therapy; Prognosis; Terminology as Topic
• ISSN: 1432-1963
• DOI: 10.1007/s00292-010-1365-3

Until recently, two major types of colorectal epithelial polyps were distinguished: the adenoma and the hyperplastic polyp. While adenomas - because of their cytological atypia - were recognized as precursor lesions for colorectal carcinoma, hyperplastic polyps were perceived as harmless lesions without any potential for malignant progression, mainly because hyperplastic polyps lack cytological atypia. Meanwhile, it is evident that the lesions formerly classified as hyperplastic represent a heterogeneous group of polyps, some of which exhibit a significant risk of neoplastic progression. These lesions show characteristic epigenetic alterations not commonly seen in colorectal adenomas and progress to colorectal carcinoma via the so-called serrated pathway (CIMP pathway). This group of polyps is comprised not only of hyperplastic polyps, but also of sessile serrated adenomas (SSA), traditional serrated adenomas (TSA) and mixed polyps, showing serrated and "classical" adenomatous features. In a consensus conference of the working group of gastroenterological pathology of the German Society of Pathology, standardization of nomenclature and diagnostic criteria as well as recommendations for clinical management of these serrated polyps were formulated and are presented herein.