The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules

• Published in: Clinical and experimental hypertension (1993) 2010-11, Vol.32 (7), p.464-468
• Main Authors: Zhang, Linan, Guo, Fang, Guo, Huicai, Wang, Haiyan, Zhang, Zhe, Liu, Xu, Shi, Xiaolu, Gou, Xiangbo, Su, Qian, Yin, Jian, Wang, Yongli
• Format: Article
• Language: English
• Subjects: adenylyl cyclase; Adenylyl Cyclases - metabolism; angiotensin II; Angiotensin II - metabolism; Animals; ATPase; Biological Transport; dopamine; Dopamine - metabolism; Humans; Hypertension - metabolism; Hypertension - physiopathology; Kidney Tubules, Proximal - metabolism; Membrane Proteins - metabolism; PDZ Domains; Phosphorylation; Protein Isoforms - metabolism; protein kinase C; Protein Kinase C - metabolism; Receptor Cross-Talk - physiology; Receptors, Angiotensin - metabolism; Receptors, Dopamine - metabolism; renal proximal tubule; Signal Transduction - physiology; Sodium-Potassium-Exchanging ATPase - metabolism; Tight Junction Proteins
• ISSN: 1064-1963; 1525-6006
• DOI: 10.3109/10641963.2010.496516

Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na+ and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na+, K+-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA α1-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-β, PKC-ζ), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.