On the role of subthreshold currents in the Huber–Braun cold receptor model

We study the role of the strength of subthreshold currents in a four-dimensional Hodgkin–Huxley-type model of mammalian cold receptors. Since a total diminution of subthreshold activity corresponds to a decomposition of the model into a slow, subthreshold, and a fast, spiking subsystem, we first elu...

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Bibliographic Details
Published in:Chaos (Woodbury, N.Y.) N.Y.), 2010-12, Vol.20 (4), p.045107-045107-11
Main Authors: Finke, Christian, Freund, Jan A., Rosa, Epaminondas, Braun, Hans A., Feudel, Ulrike
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Cell Membrane - metabolism
Cold Temperature
Ion Channel Gating
Models, Neurological
Nonlinear Dynamics
Receptors, Cell Surface - metabolism
Time Factors
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Summary:We study the role of the strength of subthreshold currents in a four-dimensional Hodgkin–Huxley-type model of mammalian cold receptors. Since a total diminution of subthreshold activity corresponds to a decomposition of the model into a slow, subthreshold, and a fast, spiking subsystem, we first elucidate their respective dynamics separately and draw conclusions about their role for the generation of different spiking patterns. These results motivate a numerical bifurcation analysis of the effect of varying the strength of subthreshold currents, which is done by varying a suitable control parameter. We work out the key mechanisms which can be attributed to subthreshold activity and furthermore elucidate the dynamical backbone of different activity patterns generated by this model.
ISSN:1054-1500
1089-7682
DOI:10.1063/1.3527989