Immunotoxicity activity of natural furocoumarins from milky sap of Ficus carica L. against Aedes aegypti L

Ficus carica L., its fruits are delicious and can be eaten by human. Its leaves are commonly used to cure hemorrhoid and clear away heart ache. The milky sap of F. carica have a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an lethal concentration (LC50) value of...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2011-09, Vol.33 (3), p.515-518
Main Authors: Chung, III-Min, Kim, Sun-Jin, Yeo, Min-A, Park, Se-Won, Moon, Hyung-In
Format: Article
Language:English
Subjects:
Aedes
Aedes aegypti
Animals
Carica
Ficus - chemistry
Ficus carica
Ficus carica L
furocoumarins
Furocoumarins - immunology
Furocoumarins - pharmacology
immunotoxicity effects
Immunotoxins - immunology
Immunotoxins - isolation & purification
Immunotoxins - pharmacology
Insecticides
Larva - immunology
Larva - parasitology
Lethal Dose 50
Methoxsalen - analogs & derivatives
Methoxsalen - immunology
Methoxsalen - pharmacology
milky sap
Mosquito Control - methods
Plant Extracts - immunology
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
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Summary:Ficus carica L., its fruits are delicious and can be eaten by human. Its leaves are commonly used to cure hemorrhoid and clear away heart ache. The milky sap of F. carica have a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an lethal concentration (LC50) value of 10.2 μg/ml and an LC90 value of 42.3 μg/ml. Two natural furocoumarins, 5-methoxypsoralen and 8-methoxypsoralen were isolated from the milky sap of F. carica. The LC50 value of 5-methoxypsoralen and 8-methoxypsoralen were 9.4 and 56.3 μg/ml, respectively. The above indicates that major compounds may play a more important role in the toxicity of the milky sap of F. carica.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923973.2010.543907