Cellular IRES-mediated translation: The war of ITAFs in pathophysiological states

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has received increased attention during recent years due to its emerging significance for many physiological and pathological stress conditions in eukaryotic cells. Expression of genes bearing IRES elements in thei...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2011-01, Vol.10 (2), p.229-240
Main Authors: Komar, Anton A, Hatzoglou, Maria
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Mitosis
Neovascularization, Pathologic - metabolism
Organogenesis
Protein Biosynthesis
Proteins
Regulatory Sequences, Ribonucleic Acid
Review
RNA, Messenger - chemistry
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
Transcription Factors - metabolism
Transcription Factors - physiology
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Summary:Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has received increased attention during recent years due to its emerging significance for many physiological and pathological stress conditions in eukaryotic cells. Expression of genes bearing IRES elements in their mRNAs is controlled by multiple molecular mechanisms, with IRES-mediated translation favored under conditions when cap-dependent translation is compromised. In this review, we discuss recent advances in the field and future directions that may bring us closer to understanding the complex mechanisms that guide cellular IRES-mediated expression. We present examples in which the competitive action of IRES-transacting factors (ITAFs) plays a pivotal role in IRES-mediated translation and thereby controls cell-fate decisions leading to either pro-survival stress adaptation or cell death.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.10.2.14472