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Suppression of Oral Tolerance by Lactococcus lactis in Mice

Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4 + CD25 + cells was incr...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (3), p.599-601
Main Authors: SAKAI, Tohru, HIROTA, Yuko, NAKAMOTO, Mariko, SHUTO, Emi, HOSAKA, Toshio, MAKINO, Seiya, IKEGAMI, Shuji
Format: Article
Language:English
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Summary:Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4 + CD25 + cells was increased in DO11.10 mice orally given OVA, but this increase of CD4 + CD25 + cells were suppressed in L. lactis-fed DO11.10 mice.
ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.100714