Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (17), p.7086-7090
Main Authors: Hicken, Corinne E, Linbo, Tiffany L, Baldwin, David H, Willis, Maryjean L, Myers, Mark S, Holland, Larry, Larsen, Marie, Stekoll, Michael S, Rice, Stanley D, Collier, Tracy K, Scholz, Nathaniel L, Incardona, John P
Format: Article
Language:English
Subjects:
adults
Animals
Biological Sciences
cardiac output
Crude oil
cytochrome P-450
Cytochrome P-450 Enzyme System - biosynthesis
Danio rerio
Ecosystem
ecosystems
embryogenesis
Embryos
Female
Fish
Fish Diseases - chemically induced
Fish Diseases - enzymology
Fish Diseases - pathology
Gravel
Heart
Heart failure
Heart Failure - chemically induced
Heart Failure - enzymology
Heart Failure - pathology
Heart Failure - veterinary
Larvae
Male
Marine fishes
Morphology
Mortality
Myocardium - enzymology
Myocardium - pathology
Oil
Oil pollution
Oil spills
oils
petroleum
Petroleum - toxicity
pollution
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - toxicity
protective effect
Salmon
survival
Swimming
Toxicity
Water Pollutants, Chemical - toxicity
Zebrafish - metabolism
Zebrafish Proteins - biosynthesis
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Summary:Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1019031108