Pathological 99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease

• Published in: Acta radiologica (1987) 2011-02, Vol.52 (1), p.52-58
• Main Authors: Bucerius, Jan, Joe, Alexius Y, Herder, Ellen, Brockmann, Holger, Biermann, Kim, Palmedo, Holger, Tiemann, Klaus, Biersack, Hans-Jürgen
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cardiology. Vascular system; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary heart disease; Exercise Test; Female; Follow-Up Studies; Heart; Heart Diseases - complications; Heart Diseases - diagnostic imaging; Humans; Image Processing, Computer-Assisted; Kaplan-Meier Estimate; Male; Medical sciences; Myocardial Perfusion Imaging - methods; Radiopharmaceuticals; Technetium Tc 99m Sestamibi
• ISSN: 0284-1851; 1600-0455
• DOI: 10.1258/ar.2010.090482

Background Only few data are available regarding the prognostic impact of myocardial perfusion scintigraphy with 99mTc-sestamibi (MPS) regarding emerging cardiac events in elderly patients Purpose To evaluate the prognostic value of MPS regarding emerging cardiac events in patients aged ≥70 years with known or suspected coronary artery disease (CAD). Material and Methods One hundred and thirty-three patients (74.6 ± 3.7 years) who underwent exercise or pharmacological stress/rest MPS were included in this analysis. Semi-quantitative visual interpretation of MPS images was performed and Summed-Stress- (SSS), Summed-Difference- (SDS), and Summed-Rest Scores (SRS) were calculated. Multivariate logistic regression analyses were calculated for evaluation of the independent prognostic impact of MPS results and several cardiac-related patient characteristics with regard to emerging cardiac events. Kaplan-Meier survival- and log rank analyses were calculated for assessment of cardiac event-free survival. Results Pathological SSS (OR: 3.3), angina (OR: 2.7) and ischemic ECG (OR: 3.0) were independently associated with cardiac events. Patients with pathological SSS (p = 0.005) and ischemic ECG (p = 0.012) had a significantly lower incidence of cardiac event-free survival. Conclusion Pathological MPS is independently associated with emerging cardiac events predicting a significantly lower incidence of cardiac event-free survival in patients aged ≥70 years.