Cholestatic hepatitis related to amoxicillin

While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amo...

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Bibliographic Details
Published in:Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2011-10, Vol.34 (4), p.357-358
Main Authors: Chaabane, Nabil Ben, Safer, Leila, Njim, Leila, Zakhama, Abdelfatteh, Saffar, Hamouda
Format: Article
Language:English
Subjects:
Adult
amoxicillin
Amoxicillin - adverse effects
Anti-Bacterial Agents - adverse effects
Chemical and Drug Induced Liver Injury - diagnosis
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - etiology
Cholagogues and Choleretics - administration & dosage
Cholagogues and Choleretics - therapeutic use
cholestasis
Cholestasis - diagnosis
Cholestasis - drug therapy
Cholestasis - etiology
Female
Hepatitis
Humans
Liver Function Tests
Treatment Outcome
Ursodeoxycholic Acid - administration & dosage
Ursodeoxycholic Acid - therapeutic use
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Summary:While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amoxicillin treatment.
ISSN:0148-0545
1525-6014
DOI:10.3109/01480545.2010.545067