EFFECTS OF ANTACIDS ON ABSORPTION, EXCRETION AND METABOLISM OF CEFTERAM PIVOXIL

Effects of various antacids (sodium bicarbonate, aluminium hydroxide gel) and an H2-blocker (cimetidine) on the absorption and excretion of a new cephem drug for oral use, cefteram pivoxil (CFTM-PI), were studied in healthy adult volunteers. 1. No significant differences were found in serum levels o...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1990/08/25, Vol.43(8), pp.1353-1370
Main Authors: SHIMADA, JINGORO, SAITO, ATSUSHI, SHIBA, KOHYA, KAJI, MASANOBU, HORI, SEIJI, YOSHIDA, MASAKI, MIYAHARA, TADASHI
Format: Article
Language:Japanese
Subjects:
Absorption - drug effects
Administration, Oral
Adult
Aluminum Hydroxide - administration & dosage
Aluminum Hydroxide - pharmacology
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Bicarbonates - administration & dosage
Bicarbonates - pharmacology
Cefmenoxime - administration & dosage
Cefmenoxime - analogs & derivatives
Cefmenoxime - pharmacokinetics
Cimetidine - administration & dosage
Cimetidine - pharmacology
Drug Interactions
Humans
Male
Sodium - administration & dosage
Sodium - pharmacology
Sodium Bicarbonate
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Summary:Effects of various antacids (sodium bicarbonate, aluminium hydroxide gel) and an H2-blocker (cimetidine) on the absorption and excretion of a new cephem drug for oral use, cefteram pivoxil (CFTM-PI), were studied in healthy adult volunteers. 1. No significant differences were found in serum levels of CFTM and CFTM-A (an inactive isomer of cefteram (CFTM)) or their urinary excretion levels (concentration, recovery rate) between the group given CFTM-PI in combination with sodium bicarbonate and that given CFTM-PI alone. 2. There were no significant differences in serum levels of CFTM and CFTM-A or their urinary excretion levels (concentration, recovery rate) between the group given CFTM-PI in combination with aluminium hydroxide gel and that given CFTM-PI alone. 3. In contrast, serum levels of CFTM and its urinary recovery rate were significantly less in the group given the drug in combination with cimetidine than in that given a single administration 2-3.5 hours and 2-4 hours after administration, respectively. Clinical considerations may remain.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.43.1353