Circulating Monocytes Are Not a Major Reservoir of HIV-1 in Elite Suppressors

Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4+ T cell counts witho...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Virology 2011-10, Vol.85 (19), p.10399-10403
Main Authors: Spivak, Adam M, Salgado, Maria, Rabi, S. Alireza, O'Connell, Karen A, Blankson, Joel N
Format: Article
Language:English
Subjects:
Biological and medical sciences
CD4-positive T-lymphocytes
DNA
DNA, Viral - genetics
DNA, Viral - isolation & purification
Fundamental and applied biological sciences. Psychology
HIV infections
HIV Infections - immunology
HIV Infections - virology
HIV Long-Term Survivors
HIV-1 - genetics
HIV-1 - isolation & purification
Human immunodeficiency virus 1
Humans
Microbiology
Miscellaneous
monocytes
Monocytes - virology
Pathogenesis and Immunity
patients
Proviruses - genetics
Proviruses - isolation & purification
therapeutics
viral load
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4+ T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4+ T cells in ES, despite permissiveness of these cells to HIV-1 viral entry ex vivo. Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.05409-11