Characterization of the cell of origin for small cell lung cancer

Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects more than 200,000 people worldwide every year with a very high mortality rate. Here, we used a mouse genetics approach to characterize the cell of origin for SCLC; in this mouse model, tumors are initiated by th...

Full description

Saved in:
Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2011-08, Vol.10 (16), p.2806-2815
Main Authors: Park, Kwon-Sik, Liang, Mei-Chih, Raiser, David M., Zamponi, Raffaella, Roach, Rebecca R., Curtis, Stephen J., Walton, Zandra, Schaffer, Bethany E., Roake, Caitlin M., Zmoos, Anne-Flore, Kriegel, Christina, Wong, Kwok-Kin, Sage, Julien, Kim, Carla F.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Epithelium
Genes, Retinoblastoma - genetics
Landes
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Mice
Mice, Transgenic
Neuroendocrine Cells - pathology
Organogenesis
Proteins
Sequence Deletion
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Tumor Suppressor Protein p53 - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects more than 200,000 people worldwide every year with a very high mortality rate. Here, we used a mouse genetics approach to characterize the cell of origin for SCLC; in this mouse model, tumors are initiated by the deletion of the Rb and p53 tumor suppressor genes in the lung epithelium of adult mice. We found that mouse SCLCs often arise in the lung epithelium, where neuroendocrine cells are located, and that the majority of early lesions were composed of proliferating neuroendocrine cells. In addition, mice in which Rb and p53 are deleted in a variety of non-neuroendocrine lung epithelial cells did not develop SCLC. These data indicate that SCLC likely arises from neuroendocrine cells in the lung.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.10.16.17012