A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference

This study was designed to determine whether a 5-HT(2C) receptor antagonist could induce a conditioned place preference indicative of reward and/or abuse potential. Here, we present the first evidence that a selective 5-HT(2C) receptor antagonist, 6-chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxa...

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Bibliographic Details
Published in:Neuroscience letters 2011-11, Vol.505 (1), p.10
Main Authors: McCorvy, John D, Harland, Aubrie A, Maglathlin, Rebecca, Nichols, David E
Format: Article
Language:English
Subjects:
Aminopyridines - pharmacology
Amphetamine - pharmacology
Animals
Behavior, Animal
Central Nervous System Stimulants - pharmacology
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Indoles - pharmacology
Male
Rats
Rats, Sprague-Dawley
Serotonin 5-HT2 Receptor Agonists - pharmacology
Serotonin 5-HT2 Receptor Antagonists - pharmacology
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Summary:This study was designed to determine whether a 5-HT(2C) receptor antagonist could induce a conditioned place preference indicative of reward and/or abuse potential. Here, we present the first evidence that a selective 5-HT(2C) receptor antagonist, 6-chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide hydrochloride (CEPC), can potentiate a low dose (0.5 mg/kg) amphetamine-induced positive conditioned place preference (CPP). CEPC did not produce any CPP given alone at doses of either 2.0 or 4.0 mg/kg, whereas low dose amphetamine alone produced only a slight, but statistically nonsignificant, place preference. These studies suggest that 5-HT(2C) receptor antagonists can indirectly potentiate the rewarding effects of amphetamine, and perhaps other psychostimulants. If the results can be translated to man, putative 5-HT(2C) receptor antagonist treatments for anxiety or depression may enhance or potentiate the rewarding effects of drugs of abuse such as amphetamine, which release dopamine.
ISSN:1872-7972
DOI:10.1016/j.neulet.2011.07.036