Survival of patients with hematological malignancy admitted to the intensive care unit: prognostic factors and outcome compared to unselected medical intensive care unit admissions, a parallel group study

Abstract Improved survival in patients with hematological malignancy (HM) admitted to the intensive care unit (ICU) has largely been reported in uncontrolled cohorts from single academic institutions. We compared hospital mortality between 147 patients with HM and 147 general medical admissions to f...

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Published in:Leukemia & lymphoma 2012-02, Vol.53 (2), p.282-288
Main Authors: Hill, Quentin A., Kelly, Richard J., Patalappa, Chetan, Whittle, Annika M., Scally, Andrew J., Hughes, Anthony, Ashcroft, A. John, Hill, Anita
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
APACHE
cancer
Female
Follow-Up Studies
Hematologic Neoplasms - mortality
Hematologic Neoplasms - therapy
hematological malignancy
Hospital Mortality - trends
Humans
intensive care
Intensive Care Units - statistics & numerical data
Male
Middle Aged
Patient Admission
Prognosis
Retrospective Studies
Severity of Illness Index
Survival
Survival Rate
Young Adult
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Summary:Abstract Improved survival in patients with hematological malignancy (HM) admitted to the intensive care unit (ICU) has largely been reported in uncontrolled cohorts from single academic institutions. We compared hospital mortality between 147 patients with HM and 147 general medical admissions to five non-specialist ICUs. The proportion of patients surviving to hospital discharge was significantly worse in patients with HM (27% vs. 56%; p < 0.001). Six-month and 1-year survival in patients with HM was 21% and 18%, respectively. HM, greater age, mechanical ventilation (MV) and acute physiology and chronic health evaluation (APACHE) II score were independent predictors of poor outcome. For patients with HM, culture proven infection, age, MV and inotropes were negative predictors. Disease-specific factors including hematological diagnosis, neutropenia, remission status, prior stem cell transplant, time from diagnosis to admission and degree of prior treatment were not predictive. Overall survival of patients with HM was worse than that recently reported from specialist units.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428194.2011.614705