Seeking gene candidates responsible for developmental origins of health and disease

ABSTRACT Human epidemiological evidence has led scientists to theorize that undernutrition during gestation is an important early origin of adult diseases. Animal models have successfully demonstrated that maternal diet could contribute to some adult diseases. Undernutrition is perceived harmful in...

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Bibliographic Details
Published in:Congenital anomalies 2011-09, Vol.51 (3), p.110-125
Main Authors: Ogawa, Tetsuo, Rakwal, Randeep, Shibato, Junko, Sawa, Chika, Saito, Tomomi, Murayama, Aya, Kuwagata, Makiko, Kageyama, Haruaki, Yagi, Michiko, Satoh, Kazue, Shioda, Seiji
Format: Article
Language:English
Subjects:
Animals
developmental origins of health and disease
Disease - genetics
Female
Fetal Nutrition Disorders - genetics
Food Deprivation
Gene Expression Regulation
Genetic Association Studies
global gene expression profiling
Health
High-Throughput Screening Assays
histone 1
Liver - anatomy & histology
Liver - metabolism
Liver - physiology
Longevity - genetics
Mice
Mice, Inbred C57BL
NADH dehydrogenase 1
neuregulin 1
Oligonucleotide Array Sequence Analysis
Pregnancy
prenatal undernutrition
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:ABSTRACT Human epidemiological evidence has led scientists to theorize that undernutrition during gestation is an important early origin of adult diseases. Animal models have successfully demonstrated that maternal diet could contribute to some adult diseases. Undernutrition is perceived harmful in pregnant women, whereas calorie restriction is a strategy proven to extend healthy and maximum lifespan in adult. This diagrammatically opposite effect of nutritional condition might provide us with hints to search for genes underlying health conditions. Here, we have initiated a study examining the effect of undernutrition on maternal and fetal livers, utilizing high‐throughput DNA microarray analysis for screening genome‐wide changes in their transcriptomes. Briefly, pregnant mice were exposed to food deprivation (FD) on gestation day (GD) 17, and cesarean section was performed on GD18. Control mice were supplied with chow ad libitum until sacrifice. Total RNA extracted from mother and fetal livers for each control and treatment (FD) was analyzed with an Agilent mouse whole genome DNA chip. A total of 3058 and 3126 up‐ (>1.5‐fold) and down‐ (1.5‐fold) and down‐ (
ISSN:0914-3505
1741-4520
DOI:10.1111/j.1741-4520.2011.00315.x