Ultrastructure of the H. pylori Microbe in Individuals Having Macrocytosis and B12 Deficiency

The incidence of Helicobacter pylori gastritis is high in India and the number of individuals with vitamin B12 deficiency is also large. An association has been found between these two factors. It is necessary to determine whether H. pylori infection may be a factor in the causation of B12 deficienc...

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Bibliographic Details
Published in:Ultrastructural pathology 2011-10, Vol.35 (5), p.204-208
Main Authors: Khubchandani, Shaila R., Kulkarni, Satish, Teckchandani, Suresh, Chitale, Arun
Format: Article
Language:English
Subjects:
Adult
B12 deficiency
Cohort Studies
Erythrocyte Indices
Erythrocytes, Abnormal - microbiology
Erythrocytes, Abnormal - ultrastructure
Gastric Mucosa - microbiology
Gastric Mucosa - ultrastructure
H. pylori
Helicobacter Infections - blood
Helicobacter Infections - microbiology
Helicobacter pylori - isolation & purification
Helicobacter pylori - ultrastructure
Humans
macrocytosis
Male
Vitamin B 12 Deficiency - blood
Vitamin B 12 Deficiency - microbiology
Young Adult
young adults
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Summary:The incidence of Helicobacter pylori gastritis is high in India and the number of individuals with vitamin B12 deficiency is also large. An association has been found between these two factors. It is necessary to determine whether H. pylori infection may be a factor in the causation of B12 deficiency and whether it is associated with any morphological changes on ultrastructural examination. A cohort-based study has been performed, which includes 505 young asymptomatic males. These cases have been investigated for presence of H. pylori and macrocytosis. The study confirms an association between H. pylori infection and B12 deficiency. It is recommended that H. pylori infection be looked for in subjects having macrocytosis of unknown etiology.
ISSN:0191-3123
1521-0758
DOI:10.3109/01913123.2011.598256