Variation in CAG and GGN repeat lengths and CAG/GGN haplotype in androgen receptor gene polymorphism and prostate carcinoma in Nigerians

Prostate cancer has become the most common cancer in Nigerian men. The growth of the prostate gland depends on circulating androgens and intracellular steroid signalling pathways. The effects of androgens are mediated through the androgen receptor (AR), a nuclear transcription factor encoded by the...

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Bibliographic Details
Published in:British journal of biomedical science 2011-01, Vol.68 (3), p.138-142
Main Authors: Akinloye, O., Gromoll, J., Simoni, M
Format: Article
Language:English
Subjects:
Aged
Androgens
Carcinoma - genetics
Case-Control Studies
Haplotypes
Humans
Male
Men
Microsatellite Repeats
Middle Aged
Nigeria
Polymorphism, Genetic
Prospective Studies
Prostate cancer
Prostatic Hyperplasia - genetics
Prostatic neoplasms
Prostatic Neoplasms - genetics
Receptors, androgen
Receptors, Androgen - genetics
Reproductive health
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Summary:Prostate cancer has become the most common cancer in Nigerian men. The growth of the prostate gland depends on circulating androgens and intracellular steroid signalling pathways. The effects of androgens are mediated through the androgen receptor (AR), a nuclear transcription factor encoded by the AR gene. The common polymorphisms, CAG and GGN repeats, in exon 1 of this gene have been implicated as possible risk factors. Thus far, existing supporting data are scanty and none are from sub-Saharan African populations. Therefore, this study investigates the possible association between AR polymorphism repeat length (CAG and GGN) and prostate cancer in Nigerians. A total of 261 subjects (70 with prostate cancer, 68 with benign prostate hyperplasia [BPH], 123 age-matched apparently normal subjects as controls) were studied. CAG and GGN repeats length were determined by fragment length analysis using GeneScan. The CAG repeat length in prostate cancer and in BPH compared to the controls was significantly different (P0.05). CAG and GGN haplotype variation showed no significant difference between cases and controls (P>0.05), except that the haplotypes CAG≥21 and GGN≤21 were more common in the control group. The results of this study, the first from sub-Saharan Africa, supports the hypothesis that reduced CAG repeat length is a risk factor for prostate cancer, and also suggests an association with BPH.
ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2011.11730341