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Psychomotor Deficits Associated With Hyponatremia: A Retrospective Analysis
Hyponatremia (serum sodium concentration [Na+]
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| Published in: | Clinical neuropsychologist 2012-01, Vol.26 (1), p.74-87 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c392t-50d8ea58ab64fdf058554ef0d8ce82e1c8a1da421d2159c4826189957b408fb13 |
| container_end_page | 87 |
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| container_title | Clinical neuropsychologist |
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| creator | Josiassen, Richard C. Filmyer, Dawn M. Geboy, Alexander G. Martin, Danielle M. Curtis, Jessica L. Shaughnessy, Rita A. Salzman, Amber Orlandi, Cesare |
| description | Hyponatremia (serum sodium concentration [Na+] |
| doi_str_mv | 10.1080/13854046.2011.628697 |
| format | article |
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Recent evidence (Renneboog, Musch, Vandemergel, Manto, & Decaux, 2006) shows that even mild hyponatremia is associated with disorders of balance/gait. This retrospective analysis explored the influence of serum [Na+] on neuropsychological (NP) measurements at baseline from 44 patients with chronic hyponatremia who participated in an efficacy and safety study of an experimental compound over a decade ago. Group mean serum [Na+] was 124.8 ± 4.9 mEq/L. Age-adjusted partial correlations were computed between serum [Na+] and NP measurements, 39% of which were statistically significant-all involving psychomotor functioning. These findings replicate and extend previous observations that psychomotor deficits are, at least in part, associated with hyponatremia in these patients. While chronic hyponatremia is known to have deleterious effects on quality of life, motor and gait disturbances represent manifestations of mild hyponatremia that have until now gone unrecognized. A new class of medication, vasopressin antagonists, has been shown to correct hyponatremia. It will be important to explore the effects of correcting hyponatremia on psychomotor functioning in individuals with hyponatremia.</description><identifier>ISSN: 1385-4046</identifier><identifier>EISSN: 1744-4144</identifier><identifier>DOI: 10.1080/13854046.2011.628697</identifier><identifier>PMID: 22087848</identifier><language>eng</language><publisher>Hove: Psychology Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Elderly/geriatric/aging ; Encephalopathy ; Female ; Gait Disorders, Neurologic - blood ; Gait Disorders, Neurologic - etiology ; Geriatrics ; Humans ; Hyponatremia ; Hyponatremia - blood ; Hyponatremia - complications ; Intelligence ; Male ; Medical sciences ; Middle Aged ; Mild cognitive impairment ; Movement disorder ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neuropsychological Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Disorders - blood ; Psychomotor Disorders - diagnosis ; Psychomotor Disorders - etiology ; Psychopathology. Psychiatry ; Regression Analysis ; Retrospective Studies ; Sodium - blood ; Vasopressin antagonists</subject><ispartof>Clinical neuropsychologist, 2012-01, Vol.26 (1), p.74-87</ispartof><rights>Copyright Taylor & Francis Group, LLC 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-50d8ea58ab64fdf058554ef0d8ce82e1c8a1da421d2159c4826189957b408fb13</citedby><cites>FETCH-LOGICAL-c392t-50d8ea58ab64fdf058554ef0d8ce82e1c8a1da421d2159c4826189957b408fb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25611194$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22087848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Josiassen, Richard C.</creatorcontrib><creatorcontrib>Filmyer, Dawn M.</creatorcontrib><creatorcontrib>Geboy, Alexander G.</creatorcontrib><creatorcontrib>Martin, Danielle M.</creatorcontrib><creatorcontrib>Curtis, Jessica L.</creatorcontrib><creatorcontrib>Shaughnessy, Rita A.</creatorcontrib><creatorcontrib>Salzman, Amber</creatorcontrib><creatorcontrib>Orlandi, Cesare</creatorcontrib><title>Psychomotor Deficits Associated With Hyponatremia: A Retrospective Analysis</title><title>Clinical neuropsychologist</title><addtitle>Clin Neuropsychol</addtitle><description>Hyponatremia (serum sodium concentration [Na+] < 136 mEq/L) is a potentially life-threatening condition. Recent evidence (Renneboog, Musch, Vandemergel, Manto, & Decaux, 2006) shows that even mild hyponatremia is associated with disorders of balance/gait. This retrospective analysis explored the influence of serum [Na+] on neuropsychological (NP) measurements at baseline from 44 patients with chronic hyponatremia who participated in an efficacy and safety study of an experimental compound over a decade ago. Group mean serum [Na+] was 124.8 ± 4.9 mEq/L. Age-adjusted partial correlations were computed between serum [Na+] and NP measurements, 39% of which were statistically significant-all involving psychomotor functioning. These findings replicate and extend previous observations that psychomotor deficits are, at least in part, associated with hyponatremia in these patients. While chronic hyponatremia is known to have deleterious effects on quality of life, motor and gait disturbances represent manifestations of mild hyponatremia that have until now gone unrecognized. A new class of medication, vasopressin antagonists, has been shown to correct hyponatremia. It will be important to explore the effects of correcting hyponatremia on psychomotor functioning in individuals with hyponatremia.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Elderly/geriatric/aging</subject><subject>Encephalopathy</subject><subject>Female</subject><subject>Gait Disorders, Neurologic - blood</subject><subject>Gait Disorders, Neurologic - etiology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Hyponatremia</subject><subject>Hyponatremia - blood</subject><subject>Hyponatremia - complications</subject><subject>Intelligence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mild cognitive impairment</subject><subject>Movement disorder</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Disorders - blood</subject><subject>Psychomotor Disorders - diagnosis</subject><subject>Psychomotor Disorders - etiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Sodium - blood</subject><subject>Vasopressin antagonists</subject><issn>1385-4046</issn><issn>1744-4144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kN9LwzAQx4Mobk7_A5G-iE-duSxtU1-kzB8TB4ooPoYsTVikbWaSKf3vbdmmbz7dcXy-d8cHoVPAY8AMX8KEJRTTdEwwwDglLM2zPTSEjNKYAqX7Xd8hcc8M0JH3HxhDSkl2iAaEYJYxyobo8dm3cmlrG6yLbpQ20gQfFd5baURQZfRuwjKatSvbiOBUbcRVVEQvKjjrV0oG86WiohFV640_RgdaVF6dbOsIvd3dvk5n8fzp_mFazGM5yUmIE1wyJRImFinVpcYJSxKqdDeVihEFkgkoBSVQEkhySRlJgeV5ki0oZnoBkxG62OxdOfu5Vj7w2nipqko0yq49zwnpkin0JN2QsnvXO6X5yplauJYD5r1FvrPIe4t8Y7GLnW0PrBe1Kn9DO20dcL4FhJei0k400vg_rj8OOe246w1nGm1dLb6tq0oeRFtZtwtN_n3lB6TrjZM</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Josiassen, Richard C.</creator><creator>Filmyer, Dawn M.</creator><creator>Geboy, Alexander G.</creator><creator>Martin, Danielle M.</creator><creator>Curtis, Jessica L.</creator><creator>Shaughnessy, Rita A.</creator><creator>Salzman, Amber</creator><creator>Orlandi, Cesare</creator><general>Psychology Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Psychomotor Deficits Associated With Hyponatremia: A Retrospective Analysis</title><author>Josiassen, Richard C. ; Filmyer, Dawn M. ; Geboy, Alexander G. ; Martin, Danielle M. ; Curtis, Jessica L. ; Shaughnessy, Rita A. ; Salzman, Amber ; Orlandi, Cesare</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-50d8ea58ab64fdf058554ef0d8ce82e1c8a1da421d2159c4826189957b408fb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Elderly/geriatric/aging</topic><topic>Encephalopathy</topic><topic>Female</topic><topic>Gait Disorders, Neurologic - blood</topic><topic>Gait Disorders, Neurologic - etiology</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Hyponatremia</topic><topic>Hyponatremia - blood</topic><topic>Hyponatremia - complications</topic><topic>Intelligence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mild cognitive impairment</topic><topic>Movement disorder</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Disorders - blood</topic><topic>Psychomotor Disorders - diagnosis</topic><topic>Psychomotor Disorders - etiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Sodium - blood</topic><topic>Vasopressin antagonists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josiassen, Richard C.</creatorcontrib><creatorcontrib>Filmyer, Dawn M.</creatorcontrib><creatorcontrib>Geboy, Alexander G.</creatorcontrib><creatorcontrib>Martin, Danielle M.</creatorcontrib><creatorcontrib>Curtis, Jessica L.</creatorcontrib><creatorcontrib>Shaughnessy, Rita A.</creatorcontrib><creatorcontrib>Salzman, Amber</creatorcontrib><creatorcontrib>Orlandi, Cesare</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neuropsychologist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josiassen, Richard C.</au><au>Filmyer, Dawn M.</au><au>Geboy, Alexander G.</au><au>Martin, Danielle M.</au><au>Curtis, Jessica L.</au><au>Shaughnessy, Rita A.</au><au>Salzman, Amber</au><au>Orlandi, Cesare</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychomotor Deficits Associated With Hyponatremia: A Retrospective Analysis</atitle><jtitle>Clinical neuropsychologist</jtitle><addtitle>Clin Neuropsychol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>26</volume><issue>1</issue><spage>74</spage><epage>87</epage><pages>74-87</pages><issn>1385-4046</issn><eissn>1744-4144</eissn><abstract>Hyponatremia (serum sodium concentration [Na+] < 136 mEq/L) is a potentially life-threatening condition. Recent evidence (Renneboog, Musch, Vandemergel, Manto, & Decaux, 2006) shows that even mild hyponatremia is associated with disorders of balance/gait. This retrospective analysis explored the influence of serum [Na+] on neuropsychological (NP) measurements at baseline from 44 patients with chronic hyponatremia who participated in an efficacy and safety study of an experimental compound over a decade ago. Group mean serum [Na+] was 124.8 ± 4.9 mEq/L. Age-adjusted partial correlations were computed between serum [Na+] and NP measurements, 39% of which were statistically significant-all involving psychomotor functioning. These findings replicate and extend previous observations that psychomotor deficits are, at least in part, associated with hyponatremia in these patients. While chronic hyponatremia is known to have deleterious effects on quality of life, motor and gait disturbances represent manifestations of mild hyponatremia that have until now gone unrecognized. A new class of medication, vasopressin antagonists, has been shown to correct hyponatremia. It will be important to explore the effects of correcting hyponatremia on psychomotor functioning in individuals with hyponatremia.</abstract><cop>Hove</cop><pub>Psychology Press</pub><pmid>22087848</pmid><doi>10.1080/13854046.2011.628697</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1385-4046 |
| ispartof | Clinical neuropsychologist, 2012-01, Vol.26 (1), p.74-87 |
| issn | 1385-4046 1744-4144 |
| language | eng |
| recordid | cdi_pubmed_primary_22087848 |
| source | Taylor and Francis Social Sciences and Humanities Collection |
| subjects | Adult Aged Biological and medical sciences Cognition Disorders - diagnosis Cognition Disorders - etiology Elderly/geriatric/aging Encephalopathy Female Gait Disorders, Neurologic - blood Gait Disorders, Neurologic - etiology Geriatrics Humans Hyponatremia Hyponatremia - blood Hyponatremia - complications Intelligence Male Medical sciences Middle Aged Mild cognitive impairment Movement disorder Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neuropsychological Tests Psychology. Psychoanalysis. Psychiatry Psychomotor Disorders - blood Psychomotor Disorders - diagnosis Psychomotor Disorders - etiology Psychopathology. Psychiatry Regression Analysis Retrospective Studies Sodium - blood Vasopressin antagonists |
| title | Psychomotor Deficits Associated With Hyponatremia: A Retrospective Analysis |
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