Detecting Pleiotropy and Epistasis Using Variance Components Linkage Analysis in jPAP

jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion...

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Bibliographic Details
Published in:Human heredity 2011-01, Vol.72 (4), p.258-263
Main Authors: Hasstedt, Sandra J., Thomas, Alun
Format: Article
Language:English
Subjects:
Analysis of Variance
Epistasis, Genetic
Genetic Linkage
Genetic Pleiotropy
Humans
Internet
Models, Genetic
Pedigree
Quantitative Trait, Heritable
Software
Software packages
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Description
Summary:jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP.
ISSN:0001-5652
1423-0062
DOI:10.1159/000331690